Airway Development and Prevention of Obstructive Sleep Apnea in Children: a case report By Juan-Carlos Quintero, DMD, MS

Obstructive sleep apnea (OSA) is a debilitating disease resulting in greater loss of life expectancy (LLE) and diminished quality of life (QOL) affecting anywhere from 3% to 7% of the US population1.  The prevalence of OSA is higher in some subpopulations such as obese adults2. Comorbidities include cardiovascular disease, renal disease, diabetes, depression,  and motor vehicle accidents among others1. The number of patients being diagnosed with OSA is increasing at an alarming rate of 15% per year likely due to increased patient and doctor awareness. From an economic perspective, the estimated annual costs of obstructive sleep apnea and its related comorbidities is estimated to be between $65 billion and $165 billion a year, according to a 2010 report published by the Harvard Medical School3.  Treatment modalities include weight loss, positional therapy, nasal decongestion, oral appliances, CPAP, soft tissue surgery – uvulopalatopharyngoplasty (UPPP), orthognathic surgery in the form of maxillo-mandibular advancement (MMA) or mandibular advancement (MA), and tracheotomy. But perhaps the most effective and least invasive modality is the one infrequently discussed in the scientific circles: prevention in children through airway development3,4,5,6,7. This article will explore the rationale and potential of preventing OSA in children at risk for OSA through proven methods of airway development and evolving diagnostic aids.  Early screening and understanding of growth and development is critical in identifying pediatric patients at risk for OSA or for developing future OSA as adults.

Breathing is a function of craniofacial anatomy and the resultant airflow resistance caused by the collapse of the structures surrounding the upper airway (Figure 1), such as the tongue. The larger the size of the pharyngeal airway, or more specifically, the larger the minimum cross sectional area (MCA) of the airway, the less collapse or obstruction that occurs during sleep when voluntary muscles such as the tongue become flaccid.  Recent studies have correlated facial dentofacial morphology with airway volume and airway dimensions have logically been correlated to risk factors for OSA4, 5, 6. Furthermore, recent advances in imaging technology have made ultralow dose cone beam computerized tomography (CBCT) such as the new iCAT FLX from Imaging Sciences International (Hartford, Pa) and everyday imaging of the airways possible with dose exposure less than a panorex and as low as 8 µSv14, 15 (Figure 2, 3, 4). The application and implication of this technology in the screening and prevention of OSA in the pediatric population are enormous. It is now possible to screen children with small airways who either have OSA, are at risk for OSA, or are at risk for developing OSA later in life, and treat accordingly.

Figure 1

Figure 1

Figure 2

Figure 2

Figure 3

Figure 3

 

Figure 4

Figure 4

Case Report

The following is a case study of an 8 year old female patient who presented for an orthodontic evaluation with a chief concern of “wanting a prettier smile”.  During the initial interview it was revealed that the patient was a chronic mouth breather, and a regular snorer. The parents also reported a lethargic disposition during the day with inattentiveness at school and not interested in sports. At the time of the exam the patient appeared to be breathing only through her mouth and had signs of venus pooling (“droopy eyes”). A 3D diagnostic session was completed consisting of photographs (figure 5) and a low dose CBCT taken on an iCAT machine using 16x13cm field of view and 4.9 sec exposure time. The evaluation revealed crowding with impacted maxillary canines in the mixed dentition, with a constricted arch form (figure 6). The CBCT radiographic study showed an extremely narrow pharyngeal airway with an MCA of 47mm2  (figure 7).  The patient also presented with adenoid hyperplasia encroaching upon the pharyngeal airspace.

Figure 5

Figure 5

Figure 6

Figure 6

Figure 7

Figure 7

Figure 8

Figure 8

The treatment plan consisted first of ENT management in the form of adenoidectomy with coblation of turbinates followed by 10 mos of orthodontic Phase I dual arch expansion treatment. Specifically the patient received a Rapid Maxillary Expander off of a 2x 6 bracket system in the upper arch and a lower removable Schwartz expander followed by a 2X6 bracket system. Final Phase I records were taken consisting of photographs and a low dose CBCT. Figure 9 shows the facial changes before and after treatment, 12 mos apart. Figures 10, 11 show the changes in the pharyngeal airway volume and cross sectional areas following adenoidectomy, coblation of turbinates and Phase I orthodontic expansion.  Figure 12 shows the resolution of the ectopically positioned permanent maxillary canines. Note the more upright and vertical positions of the canines.

Post treatment, the mother reported a dramatic improvement in the patient’s overall health, level of alertness, a reduction in daytime sleepiness, an improvement in academic performance and increased athletic activity – all signs of better sleep and oxygenation.

Figure 9

Figure 9

Figure 10

Figure 10

Figure 11

Figure 11

Figure 12

Figure 12

Discussion

Orthognathic surgery in the form of maxillomandibular advancement has been shown to be the definitive treatment for patients suffering from obstructive sleep apnea. Several studies have demonstrated a 100% success rate of OSA through MMA, when compared to CPAP or Oral Appliances, using AHI scores through polysomnograms as the measuring tool16, 17, 18. This is because Grauer et al and others have reported that  pharyngeal airspace dimensions are a function of jaw position45,5,6. It would seem only reasonable to equally expect enlargement of the pharyngeal airspace in children concurrent with the forward growth of the craniofacial complex.

Just as the airway is enlarged in non-growing patients when the face is surgically positioned forward through MMA, so can the airway be enlarged through proper inter-professional collaboration (in this case with an ENT physician) when facial -growth-friendly orthodontics are applied in children, as is demonstrated in this case report.

Conclusions

 

In children, airway issues MUST be identified and treated as early as possible.  Delays in treatment can only delay the suffering of the family and the child.  Proper screening using ultralow dose CBCT imaging and early management through inter-professional collaboration with ENT’s, pediatricians, and allergists during the growing years of the face may prevent OSA in future generations, by promoting healthy growth of the craniofacial complex, and thus pharyngeal airway development,  during childhood.

  1. Chiong, T. L. (2009). Sleep medicine essentials. Hoboken, N.J.: Wiley-Blackwell.
  2. Punjabi, N. M. (2008). The Epidemiology Of Adult Obstructive Sleep Apnea. Proceedings of the American Thoracic Society, 5(2), 136-143.
  3. The Price of Fatigue. Sleep Medicine. Harvard Medical School. The Harvard Medical Division of Sleep Medicine. December 2010.
  4. Grauer D, Cevidanes LH, Styner MA, Ackerman JL, Proffit WR. Pharyngeal airway volume and shape from cone-beam computed tomography: relationship to facial morphology. Am J Orthod Dentofacial Orthop. 2009 Dec;136(6):805-14.
  5. Abdelkarim, A. A cone beam CT evaluation of oropharyngeal airway space and its relationship to mandibular position and dentocraniofacial morphology. Journal of the World Federation of  Orthodontists. . 16 July 2012.
  6. El H, Palomo JM. Airway volume for different dentofacial skeletal patterns. Am J Orthod Dentofacial Orthop. 2011 Jun;139(6):e511-21.
  7. Pirelli P, Saponara M, Guilleminault C. June 15 2004. Rapid maxillary expansion in children with obstructive sleep apnea syndrome. Sleep. 27;(4):761-6.
  8. Villa MP, Malagola C, Pagani J, Montesano M, Rizzoli A, Guilleminault C, Ronchetti R. March 2007; Epub 2007 Jan 18. Rapid maxillary expansion in children with obstructive sleep apnea syndrome: 12-month follow-up. Sleep Med. 8(2):128-34.
  9. Villa MP, Rizzoli A, Miano S, Malagola C. May 2011; Epub 2001 March 25. Efficacy of rapid maxillary expansion in children with obstructive sleep apnea syndrome: 36 months of follow-up. Sleep Breath. 15(2):179-84.
  10. Guilleminault C, Quo S, Huynh NT, Li K. July 2008. Orthodontic expansion treatment and adenotonsillectomy in the treatment of obstructive sleep apnea in prepubertal children. Sleep. 31(7):953-7.
  11. Marino A, Ranieri R, Chiarotti F, Villa MP, Malagola C. March 2012. Rapid maxillary expansion in children with Obstructive Sleep Apnoea Syndrome (OSAS). Eur J Paediatr Dent. 13(1):57-63.
  12. Cistulli PA, Palmisano RG, Poole MD. December 15, 1998. Treatment of obstructive sleep apnea syndrome by rapid maxillary expansion. Sleep. 21(8):831-5.
  13. Miano S, Rizzoli A, Evangelisti M, Bruni O, Ferri R, Pagani J, Villa MP. April 2009; Epub 2008 August 26. NREM sleep instability changes following rapid maxillary expansion in children with obstructive apnea sleep syndrome. Sleep Med. 10(4):471-8
  14. 14.  John B. Ludlow and Cameron Walker Assessment of phantom dosimetry and image quality of i-CAT FLX cone-beam computed tomography Am J Orthod Dentofacial Orthop 2013;144:802-17
  15. Quintero, JC. New Study May Change the Face of Orthodonitcs. Orthodontic Practice US. January/February 2014- Volume 5, N0 1. Page 41-43
  16. Prinsell JR. Maxillomandibular advancement surgery in a site-specific treatment approach for obstructive sleep apnea in 50 consecutive patients. Chest. 1999 Dec;116(6):1519-29.
  17. Riley RWPowell NBGuilleminault C, Stanford University Medical Center, CA. Obstructive sleep apnea syndrome: a surgical protocol for dynamic upper airway reconstruction. J Oral Maxillofac Surg. 1993 Jul;51(7):742-7; discussion 748-9.
  18. White PD,  Wooten V, Lachner J, Guyette RF: Maxillomandibular advancement surgery in 23 pts with OSA syndrome. J Oral Maxillofac Surg  47: 1256, 1989

 

About Dr. Juan-Carlos Quintero

Dr. Juan-Carlos Quintero (AKA Dr. “Q”) received his Dental Degree from the University of Pittsburgh in Pennsylvania and Degree in Orthodontics from the University of California at San Francisco (UCSF). During this time he also received a Master’s of Science Degree in Oral Biology. This optional degree requires an extra year of formal education and research. Before moving to Florida, Dr. Quintero was in private practice in San Diego, California for one year, where he practiced with, and mentored under world-renown orthodontist Dr. Ron Roncone.

Dr. Quintero has served as National President of the American Association for Dental Research- SRG, won numerous National research competitions, published over 14 articles in peer reviewed scientific journals and currently lectures extensively both nationally and internationally. Dr. Quintero is a faculty member at the prestigious The L.D. Pankey Institute and an attending professor at Miami Children’s Hospital, Department of Pediatric Dentistry.

Dr. Quintero is immediate past-president of the South Florida Academy of Orthodontists (SFAO). He has also been featured on several television news shows, including the Discovery Channel. He is in private practice and took over the orthodontic practice of the late Dr. Lindsey Pankey, Jr. in South Miami, Fl. His academic interests include technology in orthodontics and 3D craniofacial imaging.

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